Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
نویسندگان
چکیده
Ubiquitin-containing inclusion bodies are characteristic features of numerous neurodegenerative diseases, but whether ubiquitin plays a functional role in the formation of these protein deposits is unclear. In this issue, Bersuker et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201511024) report that protein misfolding without ubiquitylation is sufficient for translocation into inclusion bodies.
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عنوان ژورنال:
دوره 213 شماره
صفحات -
تاریخ انتشار 2016